血浆TNF-α浓度对慢性荨麻疹的诊断价值

摘要

Objective To investigate the changes of plasma necrosis factor-α concentration in patients with chronic urticaria and analyze its diagnostic value. Methods 86 patients with chronic urticaria and 86 healthy controls were enrolled in this study. Determining plasma tumor necrosis factor-α (TNF-α) concentration with ELISA. Statistical analysis was taken. Results Plasma TNF-α concentration was significantly higher in patients than those of healthy controls (4.2 ±1.8 ng/ml vs 1.8 ±0.7)ng/ml, P2.8 ng/ml) that dignosed chronic urticaria with high sensitivity (83.1% ) and specificity (79. 1% ) respectively. Conclusion TNF-α may be involved in pathogenesis of chronic urticaria, and its concentration can effectively in diagnosis of chronic urticaria.%目的:揭示慢性荨麻疹患者血浆肿瘤坏死因子-α(TNF-α)浓度的变化,分析其对慢性荨麻疹的诊断价值.方法:选取门诊治疗的慢性荨麻疹患者及健康体检者各86例,ELISA检测血浆TNF-α浓度,对数据进行统计分析.结果:慢性荨麻疹患者血浆TNF-α浓度(4.2±1.8)ng/ml显著高于对照组(1.8±0.7)ng/ml(P2.8 ng/ml),对诊断慢性荨麻疹有较高的灵敏度(83.7%)和特异度(79.1%).结论:TNF-α可能参与慢性荨麻疹的发病机制,其浓度可有效诊断慢性荨麻疹.