Compound, pharmaceutical composition, processes for prophylaxis or treatment of infection and diseases, to decrease plasma concentrations of either or both tnf-. and o; -1 of either or both il-6 and il-8, for the prophylaxis or treatment of diabetes disease and a pain disorder in a mammal, to decrease prostaglandin production in a mammal, and to decrease the activity of the enzyme cyclooxygenase in a mammal.

摘要

"COMPOUND, PHARMACEUTICAL COMPOSITION, PROCESSES FOR PROPHYLAXIS OR TREATMENT OF INFECTION AND DISEASES, TO REDUCE PLASMA CONCENTRATIONS OF ANY OR BOTH TNF- 244 AND IL-1 AND ANY OR BOTH IL-6 AND IL-6 IL 8, FOR PROPHYLAXIS OR TREATMENT OF DIABETES DISEASE AND A PAIN DISORDER IN A MAMMALIAN, TO REDUCE THE PRODUCTION OF PROSTAGLANDINS IN A MAMMALIAN, AND, TO REDUCE THE ACTIVITY OF THE CYCLEOXYGENASE ENZYME IN A MAMMA. New selected substituted pyrimidine compounds are effective for the prophylaxis and treatment of diseases, such as diseases measured by TNF- 244, IL-1 225, IL-6 and / or IL-8, and other diseases, such as pain and diabetes. The invention encompasses new compounds, analogs, prodrugs, and pharmaceutically acceptable salts thereof, pharmaceutical compositions, and processes for the prophylaxis and treatment of diseases and other diseases or conditions involving inflammation, pain, diabetes and the like. The present invention also relates to processes for making these compounds, as well as intermediates usable in such processes.