COPD患者血清ANP、BNP和CNP测定及其临床意义

摘要

目的:探讨慢性阻塞性肺疾病(COPD)患者血清心钠素(ANP)、脑钠肽(BNP)、C型钠尿肽(CNP)水平的变化及其临床意义.方法:采用放射免疫分析79例COPD患者和36例健康对照组血清ANP、BNP和CNP水平,并进行统计分析.结果:COPD组血清ANP、BNP和CNP水平显著地高于健康对照组(t=3.6841,P＜0.01;t =11.70,P＜0.01;t =2.177,P＜0.05),但Ⅰ、Ⅱ、Ⅲ和Ⅳ级组间血清ANP、BNP和CNP水平方差检验无显著性意义(F=2.123、F=1.515、F=0.165,P均＞0.05).相互间相关性分析揭示:ANP、BNP和CNP三者间均呈显著正相关(r =0.369,P＜0.01；r=0.354,P＜0.01；r=0.426,P＜0.01).住院期间死亡的患者血清ANP、BNP和CNP水平显著地高于好转出院的患者(t=5.149,P＜0.01;t =4.875,P＜0.01；t=2.830,P＜0.01).结论:COPD患者血清ANP、BNP和CNP显著升高,且与病人的稳定情况、肺动脉压力及预后相关.%Objective To investigate the determination and clinical significance of serum atrial natriuretic peptide( ANP) , brain natriuretic peptide(BNP) and C-type natriureticpeptide(CNP) in chronic obstructive pulmonary disease patients (COPD). Methods Assay the serum ANP, BNP and CNP levels in COPD (ra =79) and healthy individuals served as control group (ra =36) with radioim-munoassay, then process the statistical analysis. Results The serum ANP,BNP and CNP levels of COPD group were remarkably higher than those in control group (t = 3.6841 ,P 0.05). The correlative analysis shows significant positive correlation among serum ANP, BNP and CNP levels(r =0.369,P<0.01 ;r=0. 354,P<0.01 ;r =0.426,P<0.01). The serum ANP, BNP and CNP levels in dead patients are particulary higher than those in discharged patients (t=5.149,P<0.01 ;t =4. 875,P<0.01 ;t = 2. 830,P <0.01). Conclusion The serum BNP level is significantly increased in COPD patients, and it is related to the stability of patient condition,pulmonary artery pressure and prognosis.