急性胰腺炎患者血浆leptin和血清hs-CRP、IL-6和IL-8检测的临床意义

摘要

Objective To explore the clinical significance of Determination of changes of plasma leptin and serum hs-CRP,IL-6, IL-8 levels in patients with acute pancreatitis. Methods Plasma leptin, serum IL-6,IL-8 (with RIA) and serum hs-CRP(with immu-no-turbidity method) levels were measured in 30 patients with acute pancreatitis and 35 controls. Results Plasma leptin and serum hs-CRP,IL-6,IL-8 levels were significantly higher than those in controls (P <0.01) . Plasma leptin level was positive correlated with serum hs-CRP,IL-6,IL-8 (r =0. 6132,0. 5786,0. 6218,P <0. 01). Conclusion Detection of plasma leptin and serum hs-CRP, IL-6, IL-8 levels is clinically useful to monitoring progress and prognosis in patients with acute pancreatitis.%目的:探讨了急性胰腺炎患者血浆leptin和血清hs-CRP、IL-6和IL-8水平的变化及临床意义.方法:应用放射免疫分析和免疫比浊法对30例急性胰腺炎患者进行了血浆leptin和血清hs-CRP、IL-6和IL-8检测,并与35名正常健康人作比较.结果:急性胰腺炎患者血浆leptin和血清hs-CRP、IL-6和IL-8水平均非常显著地高于正常人组(P＜0.01)且急性胰腺炎患者血浆leptin和血清hs-CRP、IL-6和IL-8水平呈正相关(r=0.6132、0.5786、0.6218,P＜0.01).结论:检测急性胰腺炎患者血浆leptin与血清hs-CRP、IL-6和IL-8水平的变化对观察病情发展及预后判断均有重要的临床价值.