肺炎支原体肺炎患儿血清 hs-CRP、IL-6、IL-8及肺炎支原体 DNA 检测的临床意义

摘要

Objective:Through detecting the content of hs-CRP,IL-6,IL-8 and MP-DNA in children with MPP,to investigate the clinical significance of the changes of level for the children with MPP.Methods:To choose 47 children with MPP who diagnosed to our hospital as observation group from January 2013 to December 2014,as well as 40 healthy children in our hospital during the same period as control group,to compare the levels of hs-CRP,IL-6,IL-8 and MP-DNA of children between observation group and control group.Results:(1 )The levels of hs-CRP,IL-6,IL-8 and MP-DNA in children of observation group were significantly higher than con-trol group before treatment,the difference had statistical significance(P <0.05);The levels of hs-CRP,IL-6,IL-8 and MP-DNA in chil-dren of observation group all significantly reduced after treatment,compared with the same group before treatment,the difference had statistical significance(P <0.05);The levels of hs-CRP,IL-6,IL-8 and MP-DNA in children with mild case and severe case of observa-tion group all significantly higher than control group,the change had statistical significance(P <0.05);The levels of hs-CRP,IL-6,IL-8 and MP-DNA in children with severe case were significantly higher than children with mild case,compared with the two groups,the difference had statistical significance(P <0.05).Conclusion:The levels of hs-CRP,IL-6,IL-8 and MP-DNA have an important effect in the occurrence and development of MPP,and it’s an important index in the diagnosis of MPP,the detection results have high practi-cal value and important clinical significance for the diagnosis,treatment and prognosis.%目的：通过检测肺炎支原体肺炎患儿血清 hs-CRP、IL-6、IL-8及 MP-DNA 含量，探讨其水平变化对肺炎支原体肺炎患儿的临床意义。方法：选取2013年1月至2014年12月来我院进行诊治并确诊为肺炎支原体肺炎的患儿47例作为观察组，以及同期来我院进行体检的健康儿童40例作为对照组，比较观察组患儿与对照组儿童血清 hs-CRP、IL-6、IL-8及 MP-DNA 水平。结果：（1）治疗前观察组患儿血清 hs-CRP、IL-6、IL-8及 MP －DNA 水平均显著高于对照组儿童，差异具有统计学意义（P ＜0．05）；治疗后观察组患儿血清 hs-CRP、IL-6、IL-8及 MP-DNA 水平均明显降低，与同组治疗前相比，差异具有统计学意义（P ＜0．05）；（2）治疗前观察组轻症和重症患儿血清 hs-CRP、IL-6、IL-8及 MP-DNA 水平均明显高于对照组，变化具有统计学意义（P ＜0．05）；重症患儿血清 hs-CRP、IL-6、IL-8及 MP-DNA 水平明显高于轻症患儿，两组相比，差异具有统计学意义（P ＜0．05）。结论：血清 hs-CRP、IL-6、IL-8及 MP-DNA 水平在肺炎支原体肺炎的发生、发展过程中具有重要的作用，是诊断肺炎支原体肺炎的重要指标，其检测结果对诊断、治疗以及预后都具有较高的实用价值和重要的临床意义。