探讨氨基末端 B 型钠尿肽原、心型脂肪酸结合蛋白和心肌肌钙蛋白 I联合检测用于老年重症心力衰竭（HF）的价值

摘要

目的：探讨氨基末端B型钠尿肽原（ NT-proBNP ）、心型脂肪酸结合蛋白（ H-FABP ）和心肌肌钙蛋白I（ cTnI）联合检测用于老年重症心力衰竭（ HF）的价值。方法将我院100例老年重症心力衰竭患者、60例老年非重症心力衰竭患者和60例健康体检者作为研究对象，对患者进行NT-proBNP、H-FABP和cTnI检测，进行6个月随访后，比较三组研究者不良心脏事件的发生情况，评估以上三个指标在预测死亡风险中的应用价值。结果老年重症心力衰竭患者入院首次空腹静脉血测定NT-proBNP、H-FABP和cTnI均明显高于老年非重症心力衰竭组患者和健康体检组体检者；对100例老年重症心力衰竭患者应用NT-proBNP、H-FABP和cTnI 三项联合检查，在心脏不良事件死亡预测准确率（96．00％）、诊断敏感性（96．00％）、死亡预测敏感性（94．00％）、诊断特异性（95．00％）、死亡预测特异性（95．00％）均明显高于单一指标检测效果，具有统计学意义（P＜0．05）。结论氨基末端B型钠尿肽原、心型脂肪酸结合蛋白和心肌肌钙蛋白I联合检测用于老年重症心力衰竭具有较高应用价值，能够有效评估死亡风险及预后效果。%Objective To investigate N-terminal pro-B-type natriuretic peptide ( NT proBNP ) , heart fatty acid binding protein ( H-FABP ) and cardiac troponin I ( cTnI ) combined detection for the value of the elderly patients with severe heart failure ( HF ) .Methods 100 cases of elderly patients in our hospital with severe heart failure patients and 60 cases of non elderly patients with severe heart failure and 60 cases of healthy persons as the object of study , for patients of NT proBNP , H-FABP and cTnI detection , followed up for 6 months and compared among the three groups of adverse cardiac events occurrence , the above three indicators in predicting death risk in application value .Results Elderly patients with severe heart failure patients admitted to hospital first fasting venous blood determination of NT proBNP , H-FABP and cTnI was significantly higher than that in the older nonwoven group of heart failure patients and healthy group medical researchers ;on 100 cases of elderly patients with severe application of NT proBNP in patients with heart failure , H-FABP and cTnI three joint inspection and adverse cardiac events in death forecast accuracy (96%), sensitivity (96%), death in predicting sensitivity (94%), diagnosis specificity (95%), death prediction specificity (95%) were significantly higher than that of single index detection results, with statistical significance (P<0.05).Conclusions N-terminal pro-B-type natriuretic peptide , heart type fatty acid combined with protein and cardiac troponin I combined detection has higher application value for elderly patients with severe heart failure , can effectively evaluate the risk of death and prognosis .