Objective To compared the efficacy and safety of a weight-based insulin glargine dosage adjustment regimen with those of experience-based regimen on controlling the fasting blood glucose (FBG) of inpatients with type 2 diabetic mellitus. Methods The inpatients with type 2 diabetic mellitus, who needed insulin therapy, were randomized into 0.1 group and experience group. For patients in 0.1 group, the initial dose of insulin glargine was 0.2 U/(kg-d) and the dosage was increased by 0.1 U/kg per day. While for those in experience group, the initial dose and the adjustment regimen was totally decided by endocrinologists according to theirrnindividual experiences. The target FBG was set at ≤ 7.0 mmol/L. Results No significant differences were observed between 0.1 group and experience group at the levels of FBG [ (5.9 ± 0.9) mmol/L vs. (6.0 ± 0.9) mmol/L], the goal-achieving durations [ (3.3 ± 1.4) vs (3.2 ±1.3d) ], the daily dosages of insulin glargine at the end point [(0.43 ± 0.14) vs. (0.48 ± 0.17) U/(kg·d)] and hypoglycemia incidence (3/35 vs. 5/36) (all P> 0.05). Conclusions The adjustment regimen of insulin glargine based on weight is a simple, effective and safe method to control FBG in inpatients with type 2 diabetic mellitus.%目的:比较一种简易的甘精胰岛素剂量调整方案——按体重调整剂量与按经验调整剂量在控制住院2型糖尿病患者空腹血糖(fasting blood glucose,FBG)中的有效性和安全性.方法:住院2型糖尿病患者需要胰岛素治疗者随机分为“0.1组”和“经验组”.0.1组甘精胰岛素起始剂量为0.2 U/(kg·d),调整剂量方案为每天增加0.1 U/kg；经验组甘精胰岛素的起始剂量及调整剂量方案依据内分泌专业高级职称医师个人经验而定.FBG的目标值定为≤7.0 mmol/L.结果:0.1组与经验组FBG达标时FBG水平(5.9±0.9 vs 6.0±0.9) mmol/L、达标时间(3.3±1.4 vs 3.2±1.3)d、甘精胰岛素日剂量(0.43±0.14vs 0.48±0.17)U/(kg·d)及低血糖发生率(3/35 vs 5/36)均无差异(均P＞0.05).结论:对于控制住院2型糖尿病患者的FBG,按体重调整甘精胰岛素剂量的方案简单易学,安全有效.
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