住院2型糖尿病患者使用甘精胰岛素或中性鱼精蛋白锌胰岛素联合口服药疗效观察

摘要

Objective The purpose is to observe the clinical effect and safety of insulin used to treat T 2DM patients who have not been well controlled by OAD .Methods One hundred and twenty candidates were divided in-to two groups and were treated with glargine and NPH respectively for two weeks.Results FBG ,2 h BG and GSP all decreased below the baselines ( P <0 .05) for both two groups .There is no statistical difference within these two groups ( P >0 .05) .The occurrence rate of low blood glucose is 3% for Glagine group and 10% for NPH group .This has statistical difference ( P <0 .05) .The weight gains (1 .4 ± 0 .3)kg for Glargine group and (1 .4 ± 0 .3)kg for NPH group ,which shows no statistical difference ( P >0 .05) .The cost for one group who used Glargine is more than the other group who used NPH( P<0 .05) .Conclusion It is safer to use glargine than to use NPH to treat these patients not controlled by OAD ,except that the cost is just a little bit more than NPH.%目的：观察基础胰岛素对于口服降糖药（OAD）控制不佳的2型糖尿病（T2DM ）的临床疗效和安全性。方法120例OAD控制不佳的 T2DM 患者睡前分别加用甘精胰岛素（Gla）和中性鱼精蛋白锌胰岛素（NPH），每组60例治疗2周。结果2组空腹血糖（FBG）、餐后2 h血糖（2 h BG）、糖化血清蛋白（GSP）均较基线下降（ P ＜0．05），但组间差异无统计学意义（ P ＞0．05）。Gla组低血糖发生率为3％，NPH组为10％，2组比较差异有统计学意义（ P ＜0．05）。Gla组体质量增加（1.4±0.3）kg ，NPH组增加（1.4±0.3）kg ，2组比较差异无统计学意义（ P ＞0．05）。Gla组胰岛素用量和治疗费用大于NPH组（P＜0．05）。结论对于 OAD控制不佳的T2DM患者加用Gla更安全，治疗费用略高于NPH。