Comparative Effectiveness, Safety, and Indications of Insulin Analogues in Premixed Formulations for Adults With Type 2 Diabetes. Executive Summary. Effective Health Care Report Number 14

摘要

Although oral antidiabetic agents are used as first-line agents in patients with type 2 diabetes, insulin is required in a significant number of patients at some stage during the management of diabetes to maintain optimal glycemic control. Insulin use has been suggested as a first-line therapy in patients with type 2 diabetes, either as an add-on therapy to the existing noninsulin antidiabetic medications or as a replacement for noninsulin medications. According to the National Health Interview Survey, 28 percent of patients with type 2 diabetes are using insulin either alone (16 percent) or in combination with oral antidiabetic agents (12 percent). To mimic the release of insulin from pancreatic beta-cells in response to food intake, near-physiologic insulin replacement regimens involve giving insulin at specific times in relation to meals.