Objective To observe the protective effects of priming glutathion (GSH) during cardiopulmonary bypass on myocardium in the surgery for acyanotic congenitai heart disease. Methods Thirty patients with acyanotic congenitai heart disease were randomly divided into two groups: trial group (n = 15) received GSH in pump priming (20 mg/kg), and control group (n = 15) received the same dose of saline solution. Blood samples from artery and vein were obtained before the surgery, and 2, 12, 24, and 48 h after surgery. Levels of LDH, CK, CK-MB, and AST were detected at various time points. Results The levels of LDH and CK in trial group at 12, 24, and 48 h after surgery were significantly lower than those in control group (P< 0.05 or 0.01), level of AST at 2, 12, 24, and 48 h were lower (P< 0.05 or 0.01), and levels of CK-MB at 2, 12, and 24 h were lower (P< 0.05 or 0.01). Conclusion Priming glutathion shows effective myocardial protection in the surgery for acyanotic congenitai heart disease.%目的:观察体外循环预充还原型谷胱甘肽对非紫绀型先心痛术中的心肌保护作用.方法:将30例非紫绀型先天性心脏病患儿随机分为两组,实验组(n=15)在体外循环预充液中加入还原型谷胱甘肽(剂量20 mg/kg),对照组(n=15)在体外循环预充液中加入等量的盐水.于术前、主动脉开放2、12、24、48 h五个时间采患儿动或静脉血,分别测乳酸脱氢酶(LDH)、血清肌酸激酶(CK)、血清肌酸激酶同工酶(CK-MB)、天门冬氨酸氧基转移酶(AST).结果:实验组血清LDH、CK在主动脉开放12、24、48 h较相同时间的对照组有显著减低(P<0.05或0.01);实验组血清AST在主动脉开放2、12、24、48 h较相同时间的对照组有显著减低(P<0.05或0.01);实验组血清CK-MB在主动脉开放2、12、24 h较相同时间的对照组有显著减低(P<0.05或0.01),差异具有统计学意义.结论:体外循环预充还原型谷胱甘肽对非紫绀型先心病术中具有心肌保护作用.
展开▼
