中国广东地区汉族人群载脂蛋白E基因型与糖尿病肾病的相关性研究

摘要

Objective To explore the relationship between apolipoprotein E ( ApoE ) genotype and diabetic nephropathy (DN) in Chinese Han population of Guangdong province. Methods 63 cases of DN patients were selected as group A; 57 diabetes patients without complications as group B; 55 healthy persons as group C. ApoE genotype of all objects were measured. Results ApoE2 in the group A was the highest, while the differences in other groups were not obvious. Detection of ApoE3 and ApoE4 was not obvious in three groups. The Level of triglyceride (TG) was highest inε2 group, and the level of total cholesterol (TC) and low density lipoprotein LDL-C were highest in ε4 groups. Conclusions In Chinese Han population of Guangdong province , ApoE gene polymorphism and DN are closely interrelated , and the occurrence ofε2 is proportionate to DN.%目的：探究中国广东地区汉族人群中载脂蛋白E（ApoE）基因型与糖尿病肾病（DN）之间的关系。方法：将63例DN 患者作为甲组；将57例糖尿病未并发 DN 患者作为乙组；同时选择健康者55例作为丙组。3组均为中国广东地区汉族人。分别对所有对象的ApoE基因型进行测定。结果：ApoE2在甲组出现率最高（P＜0．05），在乙组和丙组比较差异无显著性。ApoE3、ApoE4在3组中出现率比较差异无显著性。ε2组的甘油三酯（TG）水平最高；ε4组的总胆固醇（TC）及低密度脂蛋白LDL-C水平最高。结论：中国广东地区汉族人群中，ApoE基因型与DN的发生有着密切的联系；等位基因ε2的出现率与DN的发生率成正比。