兰州地区不同尿酸水平与代谢综合征的患病率及其关系

摘要

目的：了解甘肃兰州地区成人血尿酸水平（serum uric acid ，SUA）和代谢综合征（metabolic syndrome ，MS）的患病情况及其关系。方法：采用随机抽样方法选取2364例居民进行流行病学调查，分别根据SUA和MS的4个组分进行分组，分析SUA水平与MS患病率及其组分的关系。结果：兰州地区MS患病率为20．13％，女性高于男性（男17．37％，女23．22％，P ＜0．05）；高尿酸血症（HUA）人群中MS患病率明显高于正常人群（32．40％ vs．17．70％，P ＜0．05）；随着SUA 水平的增加， MS患病率及其各组分的异常均呈增加趋势（P ＜0．05）；同时 MS 患病风险也增加，以尿酸第1四分位水平为参照，第2，3，4分位人群 MS 患病风险分别为：男性2．33（1．45～3．71），2．33（1．45～3．71），2．44（1．53～3．89）；女性1．58（0．97～2．56），2．54（1．60～4．00），5．29（3．41～8．22）。随着MS组分的增加， SUA 水平逐渐升高，HUA患病率亦逐渐升高（P ＜0．05）。结论：MS各组分与SUA 水平密切相关，提示应对MS进行综合防控，并注重对尿酸的监测。%Objective To investigate the correlation of serum uric acid (SUA) level with the prevalence of metabolic syndrome (MS). Methods A random, multi-stage cross-sectional study was performed in 2364 resuden, aged from 20 to 74, in Lanzhou, Gansu province.The resudents were divided into groups according to the level of SUA or 4 components of MS. The relationship between SUA and MS was analyzed. Results The overall morbidity of MS was 20.13 % in Lanzhou , and the morbidity of MS was higher in female than that in male (23.22% vs. 17.37%, P < 0.05);The prevalences of MS was higher in the hyperuricemia (HUA) people than that in the healthy people (32.40 % vs. 17.70 %,P < 0.05); With the increase of SUA level, the morbidity rates of MS and its components increased;The risk of MS showed a gradual increase with the SUA level, the risk of MS(odds ratio,95%CI)in sex-specific quartiles of SUA was 2.33(1.45 ~ 3.71),2.33(1.45 ~3.71),2.44(1.53 ~ 3.89)in male;and 1.58(0.97~2.56),2.54(1.60 ~ 4.00),5.29(3.41 ~ 8.22)in female. The more the components of MS , the higher the SUA level was found for both the male and the female subjects , with the higher rate of HUA morbidity(P < 0.05). Conclusion There is a significant association between SUA level and MS, as well as the MS components. Comprehensive prevention and control should be taken for the reduction of the risk factors, and much attention should be paid to monitor the SUA level.