胸腺肽α1配合血浆置换治疗慢性乙型重型肝炎的效果观察

摘要

目的 观察胸腺肽α1配合人工肝血浆置换治疗慢性乙型重型肝炎患者的效果.方法 48例慢性乙型重型肝炎患者在常规治疗的基础上给予胸腺肽α1配合血浆置换治疗,观察疗效.结果 患者治疗后TBIL、ALT、血氨均有非常显著性降低(P＜0.01),血清HBV DNA定量极显著降低(P＜0.005),ALB、PTA均有明显升高(P＜0.05或P＜0.01);治疗后半年随访,存活34例(70.8%).结论 胸腺肽α1配合血浆置换治疗慢性乙型重型肝炎安全、有效.%Objective To evaluate the therapeutic effect of thymosin α1 and plasma exchange in patients with chronic severe hepatitis B. Methods Conventional treatments combined with thymosin α1 and plasma exchange in 48 patients with chronic severe hepatitis B were observed. Results After treatment, the symptoms of the patients improved significantly;The TBIL, ALT and HBV DNA were reduced obviously(P＜0.01,P＜0.01,P＜0.01),while ALB and PTA increased(P＜0.05,P＜0.01). 34(70.8％)survived. Conciusion Thymosin α1 and plasma exchange in treatment of patients with chronic hepatitis B are safe and effective.