Th17/Treg细胞在原发性胆汁性肝硬化发病中的作用研究进展

摘要

原发性胆汁性肝硬化（PBC）属于一种病因未明的自身免疫性疾病。Th17细胞及Treg细胞是CD4+T细胞的两个亚群，分别起着抑制、促进炎症反应的作用，它们在分化和功能上相互抑制。PBC作为肝脏特异性的自身免疫性疾病，诸多研究提示Th17和Treg细胞数量及相关细胞因子在PBC患者中较健康者有差别，但其具体机制仍不清楚。近年来，它们在PBC发病中的变化越来越成为研究的热点。本文重点介绍Treg细胞和Th17细胞的研究现状及其在PBC发病机制中的作用。%Primary biliary cirrhosis (PBC) is a kind of autoimmune diseases with unknown etiology. Th17 cells and Treg cells are two subpopulations of CD4+T cells,plays suppression of,or promotion of inflammatory reactions respectively. They inhibit each other in the differentiation and function. Many studies suggest that Th17 and Treg cells,and related cytokines differ in PBC patients from in healthy persons,but the exact mechanism remains unclear. In recent years,their changes in the pathogenesis of PBC has become a hot topic. This review focuses on the research about Treg cells and Th17 cells and their roles in the patho-genesis of PBC.