T-CELL REGULATION IN T-CELL MEDIATED DISEASES BY REDUCING PATHOGENIC FUNCTION OF TH17 IN A HUMAN SUBJECT THROUGH TREATMENT WITH A NITROXIDE

摘要

A method of reducing pathogenic T-helper cell activity in a human subject in need thereof is disclosed. The method comprises administering to the human subject, known to have a condition mediated by one or more differentiated T-helper cells responsive to Cd51, an effective amount of a nitroxide antioxidant, where the nitroxide antioxidant increases Cd51 expression, thereby reducing pathogenic T-helper cell activity. In some embodiments, the condition is an autoimmune disease.