Objective To describe the quality of life of gastrointestinal tumor patients before and after chemotherapy and to explore its influencing factors. Methods By convenient sampling, a survey was made among 84 gastrointestinal tumor patients before and after chemotherapy. The demographic and medical data of subjects were collected by a self-designed general information questionnaire and Quality of Life questionnaire of the European Organization for Research and Treatment of Cancer (EORTC QLQ-C30 version3.0). All data were analyzed with descriptive statistics and variance (ANOVA) analysis. Multiple stepwise regression was used to analyze the factors that affected the quality of life during chemotherapy. Results There were statistically significant differences of the physical functioning, social functioning, emotional functioning, global health status, fatigue, loss of appetite, astriction, financial difficulties at different stages of treatment for patients with alimentary tumor(P<0.01). There were six factors that could have influenced their quality of life, including clinical stage, radiotherapy, education, KPS, nursing staff and gender(P<0.01). Conclusion The quality of life of gastrointestinal tumor patients during the chemotherapeutic period remains in a low level. Health care workers should focus on the main influence factors so as to improve gastrointestinal tumor patients ' quality of life during the chemotherapeutic period.%目的：描述消化道肿瘤患者化疗不同阶段生存质量水平变化并探讨其影响因素。方法采用便利抽样的方法，选择符合入选标准的84例患者，应用一般资料问卷和欧洲癌症研究与治疗组织的生存质量核心问卷量表（第3版，中文版）来收集资料；采用方差分析，比较患者化疗不同阶段生存质量的差异，使用多元逐步回归确定影响生存质量的主要因素。结果患者躯体功能、社会功能、情绪功能、总体状况、疲乏、食欲下降、便秘、经济困难等分值在化疗前后比较，差异有统计学意义（P＜0.01）。影响患者生存质量的因素有临床分期、文化程度、化疗同时放疗、卡氏体能评分、主要陪护人员是否直系亲属和性别（P＜0.01）。结论消化道肿瘤患者在化疗期间生存质量整体水平较低，针对影响患者生存质量的主要因素，临床护理人员应予以足够重视，并采取积极的应对措施，以改善患者化疗期间的生存质量。
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