以芳甲醛、芳乙酮和2-肼基-5-苯基-1,3,4-噁二唑为原料,乙醇为反应溶剂,氢氧化钠为催化剂,在常温搅拌下通过三组分一锅法反应,合成了一系列具有潜在生物活性的双杂环化合物2-(3,5-二芳基-4,5-二氢吡唑-1-基)-5-苯基-1,3,4-噁二唑,产物经过IR、1HNMR、13 CNMR得到确证.该方法反应条件温和、产率高、操作简单.%A series of bi-heterocyclic compounds possessing potential biological activities, 2-(3,5-diaryl-4, 5-dihydropyrazol-l-yl)-5-phenyl-l,3,4-oxadiazoles, are synthesized at room temperature via one-pot three-component condensation of aromatic aldehydes, acetophenones and l-( 5-phenyl-l, 3, 4-oxadiazoL2-yl) hydrazine using ethanol as solvent and sodium hydroxide as catalyst. The products are confirmed by IR, 1HNMR and 13CNMR. This method has advantages of mild conditions, high yield and simple work-up procedure.
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