小剂量肠溶阿司匹林对真性红细胞增多症患者凝血功能的影响

摘要

Objective:To investigate the effect of low-dose enteric-coated aspirin on coagulation function in patients with polycythemia vera.Methods:68 cases of patients with polycythemia vera were selected as the object of the study.All the patients were divided into two groups according to random number table method,each group of 34 cases.The control group was treated with hydroxyurea,and the observation group was treated with small dose enteric-coated aspirin on the control group.The blood coagulation function index,blood parameter index and bone marrow index of the two groups were compared and analyzed.Results:There were no significant differences in coagulation function,blood parameters and bone marrow parameters between the two groups before treatment (P ＜ 0.05).After treatment,the platelet count,white blood cell (WBC),hemoglobin (Hb) and red blood cell (RBC) in the observation group were significantly lower than those in the control group,the difference was statistically significant (P ＜ 0.05).The ratio of granulocyte and granulocyte/erythrocyte in the observation group was significantly higher than that in the control group.The erythrocyte and megakaryocyte count in the obserbation group were significantly lower than that in the control group,the difference was statistically significant (P ＜ 0.05).The levels of prothrombin time (PT) and partial activated thromboplastin (APTT) in the observation group were significantly lower than those in the control group,the difference was statistically significant (P ＜ 0.05).Conclusion:In the treatment of polycythemia vera,low-dose enteric-coated aspirin is effective,can effectively improve the coagulation function,control the disease development,worthy of clinical promotion.%目的:探讨小剂量肠溶阿司匹林对于真性红细胞增多症患者凝血功能的影响.方法:选取68例真性红细胞增多症患者,按随机数表法分为两组,每组各34例.对照组行羟基脲治疗,观察组在对照组基础上加用小剂量肠溶阿司匹林治疗,比较两组凝血功能指标、血液参数指标及骨髓象指标情况.结果:治疗前,两组凝血功能、血液参数及骨髓象指标比较,差异无统计学意义(P＜0.05).治疗后,观察组血小板计数、白细胞(WBC)、血红蛋白(Hb)、红细胞(RBC)均明显低于对照组,差异有统计学意义(P＜0.05);观察组粒细胞系、粒/红细胞比值均明显高于对照组,红细胞系及巨核细胞计数低于对照组,差异有统计学意义(P＜0.05);观察组凝血酶原时间(PT)及部分活化凝血活酶时间(APTT)均明显低于对照组,差异有统计学意义(P＜0.05).结论:在真性红细胞增多症治疗过程中行小剂量肠溶阿司匹林治疗效果确切,可有效改善凝血功能,控制病情发展,值得临床推广.