自体外周血干细胞移植联合介入治疗下肢动脉缺血性疾病的效果评价

摘要

Objective:To investigate the autologous peripheral blood stem cell transplantation ( ABSCT) combined with inter-ventional therapy in treatment of chronic lower limb ischemia. Methods:38 patients with chronic lower limb ischemia were divided into 2 groups. 19 patients treated with ABSCT combined with interventional therapy were used as combined treatment group,and the other 19 patients treated with autologous peripheral blood stem cell transplantation and interventional as single interventional therapy group. The patients in two groups receieved conventional therapy. The limb pain, cold feeling, intermittent claudication, ankle brachial index (ABI) and the number of collateral vessel formation of the patients in two groups were observed before and after treatment,and the cur-ative effects in two groups were compared. Results:Compared with before treatment,the limb pain scores,cold feeling scores and inter-mittent claudication scores of the patients in two groups after treatment were significantly decreased,the differences were statistically sig-nificant (P＜0. 05),and the ABI and the number of collateral vessel formation were increased,and the difference was statistically sig-nificant (P＜0. 05). Compared with the intervention group,the limb pain,cold feeling,intermittent claudication,ABI and the number of collateral vessel formation of the patients in the combined treatment group were more significant (P＜0. 05). The total effective rate of the two groups were 89. 5% and 78. 9% ,respectively,the total effective rate in combinaed treatment group was higher than that in sin-gle interventional therapy group (P＜0. 05). Conclusion:ABSCT combined with interventional therapy is a safe and effective method for the treatment of chronic lower limb ischemia.%目的:探讨运用自体外周血干细胞移植与介入联合治疗下肢动脉缺血性疾病,并对其疗效进行临床观察.方法:本研究共入组38例下肢动脉缺血性疾病患者,依自愿原则分组,仅采用介入治疗的19例患者为单独介入组,采用自体外周血进行干细胞移植与介入联合治疗的19例患者为联合治疗组.常规治疗方案两组相同,对两组患者的疼痛感、冷感、间歇跛行、踝肱指数(ankle brachial index,ABI)、侧支血管生成数量等方面的指标进行比较,从而判断两组患者的疗效差异.结果: 在疼痛感、冷感、间歇跛行3方面两组患者均明显降低,差异具有统计学意义(P＜0. 05),ABI评分与侧支血管生成数评分方面,两组均升高,差异具有统计学意义(P＜0. 05).与单独介入组比较,联合治疗组在疼痛感、冷感、间歇跛行方面、ABI评分与侧支血管生成数评分改善更为明显(P＜0. 05).联合治疗组的有效率是89. 5% ,单独介入组的有效率是78. 9% ,联合治疗组效果显著优于单独介入组(P＜0. 05).结论: 自体外周血干细胞移植与介入结合是治疗下肢动脉缺血性疾病安全而有效的方法.