p16基因甲基化与中国人群非小细胞肺癌发生关系的Meta分析

摘要

目的：应用Meta分析的方法评价p16甲基化与中国人群非小细胞肺癌（NSCLC）的关系。方法：检索1978～2013年在Medline、Pubmed数据库以及1994～2013年CNKI、中国生物医学文献数据库、万方和维普数据库收录的所有有关p16甲基化与肺癌研究的文献，并用Review Manager 5.2软件进行统计分析。结果：纳入国内外标准的文献10篇，共有549例NSCLC患者，对照513例。数据合并结果显示，p16甲基化病例组与对照组的比值比（OR）为6.76，95%CI为（4.79%～9.54%）；经统计学分析有统计学意义（P＜0.05）。结论：p16甲基化与NSCLC发生有密切关系。%Objective:To evaluate the relationship of p16 methylation with non-small cell lung cancer (NSCLC)in Chinese populations by meta-analysis. Articles related to the p16 methylation in NSCLC published from 1978 to 2013 in the databanks including MEDLINE and published from 1978 to 2013 in the databanks including CNKI, Chinese biological medicine disk,WanFang and VIP databanks were collected, and data was analyzed by RevMan5.2 software. Results: Ten studies met our inclusion criteria, 549 NSCLC cases and 513 controls about p16 methylation were brought into the study. Odds ratios(ORs)of p16 methylation were obtained from case group and control group was 6.76(95%CI:4.79%~9.54%),Statistical analysis showed significant difference between the two groups(P<0.05).Conclusion:Methylation of p16 caused gene inactivation, and may contribute to the development of NSCLC.