胃癌组织EGFR、C-erbB-2表达及其意义

摘要

Objective To investigate the prognostic value of various histopathological features and expression of EGFR and C -erbB -2 gene in gastric cancer(GC). Methods EGFR and C -erbB -2 expression was detected in tumor samples from 64 primary GC patients. The prognostic impacts of genes expression and histopathological features were analyzed by univariate and multivariate survival analysis. Results The univariate Kaplain- Meier analysis showed that the histopathological classification, TNM stage,depth of invasion,lymph node metastasis, EGFR, C-erbB-2 expression (P ＜0.05)were related with prognosis of GC t. The multivariate Cox analysis demonstrated that histopathological classification, TNM stage, C- erbB- 2 expression were significantly independent prognostic factors(P ＜ 0.05). Conclusion For GC patients, histopathologic classification, TNM stage, C -erbB -2 expression were the independent prognostic factors as well as CerbB -2 expression was risk factor.%目的 探讨EGFR与C-erbB-2表达及病理学特征与胃癌患者术后生存的关系.方法 应用免疫组织化学方法对64例随访资料完整的胃癌标本行EGFR与C-erbB-2检测,结合病理学特征对患者3年生存期进行分析.结果 Kaplain-Meier分析显示、胃癌患者的病理分级、浸润深度、TNM分期、淋巴结转移及EGFR与C-erbB-2是影响患者预后的重要因素(P＜0.05);Cox回归多因素模型分析显示,肿瘤的病理分级[Exp(B)=3.678],TNM分期[Exp(B)=3.428]与C-erbB-2[Exp(B)=5.426]表达是独立预后因素,其中以TNM分期与C-erbB-2表达最为重要.结论 TNM分期、C-erbB-2表达是独立的预后因素,其中C-erbB-2高表达是危险因素.