Objective To explore the clinical significance of high sensitivity c - reactive Protein and serum u-ric acid in patients with transient ischemic attack. Methods 84 TIA patients were divided into three groups of A,B,C. Group A; TIA could be relieved in 60 minutes. Group B: TIA lasted for more than 60 minutes , but there were no neurological deficit and cerebral infarction,TIA. Group C. TIA deteriorated into cerebral infarction by CT or MRI within 48 -72 hours. The high sensitivity c -reactive protein and serum uric acid level was determined in all patients within 24 hours separately. 28 healthy subjects were used as control group. Results ①The high sensitivity c - reactive protein and serum uric acid levels of four groups were significantly different,. The above incices in group C were higher than those of group A and B(P<0.01). ②It showed that high levels of c - reactive protein and serum uric acid , hypertension, diabetes and dyslipidemia were the risk factors in patients with TIA with Logistic regression analysis. ③ The correlative analysis of all groups demonstrated that high sensitivity c - reactive protein and serum uric acid had significantly positive correlation (r=0.71,P<0.01). Conclusion The increase of the level of high sensitivity c - reactive protein and serum uric acid are the probable risk factors of TIA. It can also provide useful information for patients with TIA by determining the level of high sensitivity c - reactive protein and serum uric acid.%目的 探讨不同病程的短暂性脑缺血发作(TIA)患者血清超敏C反应蛋白(hs-CRP)、血清尿酸水平的差异.方法 84例临床诊断TIA首次发作患者按病程分为A、B、C三组,即TIA持续60 min内缓解为A组,TIA超过60 min并反复发作,但无持久的神经功能缺损症状,影像学检查证实无脑梗死发生者为B组,C组为TIA起病后发展为脑梗死,在48～72 h经头颅CT或MRI证实有脑梗死发生.所有患者入院后检测血清hs-CRP及血清尿酸含量,28例健康体检者作为对照组,分析TIA的危险因素,并进行hs-CRP与尿酸水平的相关性研究.结果 ①四组研究对象hs-CRP和血尿酸水平差异均具有统计学意义,经多重比较C组hs-CRP和血尿酸水平均高于A组和B组(P＜0.01),B组高于A组和对照组、A组较对照组高.②Logistic回归分析显示高尿酸血症、高hs-CRP、血脂异常、高血压、糖尿病为TIA的危险因素.③血清hs-CRP和血清尿酸水平呈正相关(r=0.71,P＜0.01).结论 血清hs-CRP和尿酸水平升高可能是TIA的危险因素,临床检测血清hs-CRP和尿酸水平,可为TIA患者的病情评估提供可靠信息.
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