过氧化物酶体增殖物激活受体γC161→T基因多态性与代谢综合征的相关研究

摘要

目的 探讨过氧化物酶体增殖物激活受体γ(PPARγ)基因C161→T多态性在宁夏人群中的分布及其与代谢综合征(MS)的关系.方法 运用横断面的调查的方法,选取175例健康对照者,平均年龄(47.30±11.6)岁和175例代谢综合征患者,平均年龄(48.73±12.50)岁,采用聚合酶链反应和限制性片段长度多态性方法(PCR-RFLP)检测人群中的PPARγ基因C161→T位点多态性,并对不同基因型患者代谢综合征的危险性进行评价.结果 ⑴代谢综合征组、对照组T等位基因频率分别为0.253、0.240,C等位基因频率分别为0.747、0.760;C、T等位基因频率在各组间分布差异无统计学意义;⑵PPARγC161CC基因型的总胆固醇(TC)水平高于TT型.结论 PPARγC161→T基因多态性与代谢综合征有关,即代谢综合征患者CC基因型总胆固醇水平相对较高.%Objective To investigate the association of PPARγC161→T gene polymorphism with metabolic syndrome in Chinese people of Ninxia. Methods Cross - sectional survey method was used for investigation. , The polymorphism of PPARγC161→T gene of 175 metabolic syndrome patients were determined by PCR - PFLP method to detect. The risk of metabolic syndrome with different genotypes was evaluated. Results (1) In the groups of metabolic syndrome and nomal health, "T" allele frequency was 0. 253 ,0. 240 respectively; and "C" allele frequency was 0. 747,0. 760 respectively. There was no significant difference between the groups. (2)The total cholesterol in CC genotypes in patients with metabolic syndrome was significantly higher than that in TT. Conclusion PPARγC161→T gene polymorphism can influence the level of lipoprotain metabolism and FBS. CC allele is associated with higher level of total cholesterol it may influence the process of metabolic syndrome.