目的：探讨胸腺肽α1（Tα1）在高龄老年人细菌性肺炎免疫调节治疗过程中血清降钙素原（PCT）与外周血 T 淋巴细胞亚群的表达变化。方法收集≥80岁高龄老年人细菌性肺炎患者58例，随机分为观察组（A1组）与对照组（A2组）各29例。A1组于入院后当天给予基础治疗+胸腺肽α1（Tα1）注射液1.6 mg，皮下注射，隔日一次，疗程2周；A2组仅给予基础治疗2周。两组于住院后第1 d 及第14 d 分别检测患者 PCT和外周血 T 淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/ CD8+）水平，观察比较各组的临床疗效。结果两组患者治疗后 PCR 较治疗前均降低，A1组降低较 A2组更明显，差异有统计学意义（P <0.05）。A1组较 A2组治疗后 CD3+、CD4+、CD4+/ CD8+免疫指标改善显著，相比结果有统计学意义（ P <0.05）。结论 Tα1辅助治疗可有效调节增强高龄老年细菌性肺炎患者机体免疫功能，降低炎症反应，改善预后。PCT 与外周血 T 淋巴细胞亚群的表达与高龄老年人细菌性肺炎有关，是高龄老年人肺部感染诊治的检测指标之一。%Objective To explore expressions of serum procalcitonin(PCT)and peripheral blood T lymphocyte subsets in aged patients with bacterial pneumonia undergoing immune regulation therapy with thymosin α1. Methods 58 elderly patients(≥80 years)with bacterial pneumonia were randomly divided into observation group(A1 group) and control group(A2 group)with 29 patients in each group. Basic treatment plus thymosin α1 injection of 1. 6 mg (subcutaneous injection,once every second day,2 weeks as a course)was given to patients in A1 group. Basic treat-ment was given to patients in A2 group for 2 weeks. PCT and levels of peripheral blood T lymphocyte subsets(CD3 + , CD4 + ,CD8 + ,CD4 + / CD8 + )were measured 1 d and 14 d after admission to hospital. Clinical effects were compared between the two groups. Results PCR decreased after treatment in both groups and A1 group decreased more signifi-cant than A2 group(P < 0. 05). CD3 + ,CD4 + and CD4 + / CD8 + improved significantly in A1 groups than those in A2 group(P < 0. 05). Conclusion Thymosin α1 can regulate immune function effectively in elderly patients with bacte-rial pneumonia. It can alleviate inflammation and improve prognosis. PCT and expressions of peripheral blood T lym-phocyte subsets have correlation with elderly patients with bacterial pneumonia,which is one of the important measure-ments in diagnosis and treatment of elderly patients with bacterial pneumonia.
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