目的:探讨骨化三醇对慢性充血性心力衰竭(CHF)患者血清脑钠肽、基质金属蛋白酶-9(MMP-9)及左心室质量指数(LVMI)的影响.方法:选择80例CHF患者,随机分为骨化三醇治疗组及常规治疗组各40例,同期收集80名门诊健康体检者为对照组.研究期1年,所有研究对象均在研究初始及研究结束时接受血清钙、脑钠肽、MMP-9水平及心脏超声检测,计算研究对象的LVMI,并记录两研究组患者心血管事件发生率及不良反应的发生率.结果:研究结束时,骨化三醇治疗组患者的脑钠肽、MMP-9水平明显低于常规治疗组(P＜0.05),其LVMI虽低于常规治疗组,但比较差异无统计学意义(P＞0.05).两组间的心血管事件及不良反应发生率比较差异无统计学意义(P＞0.05).结论:骨化三醇可能具有降低CHF患者血清脑钠肽、MMP-9水平的作用.%Objectives: To investigate the effect of calcitriol on plasma B-type natriuretic peptide (BNP) , matrix metalloproteinase-9 (MMP-9) and left ventricular mass index in patients with congestive heart failure ( CHF). Methods; Eighty patients with CHF and 80 healthy examined people as normal control group were recrui -ted to this study. Patients were randomly divided into two groups : general therapy group (n =40) and Calcitriol therapy group (n =40). All subjects were followed up for 1 year. The levels of serum Ca , BNP, MMP-9 and left ventricular mass index (LVMI) were examined in all subjects. The rates of cardiovascular events and adverse reactions in the two study groups were investigated.Results:At the end of this study , the levels of serum BNP and MMP-9 were significantly decreased in calcitriol therapy group in contrast to general therapy group( P < 0. 05 ). LVMI obtained from echocardiography decreased in calcitriol therapy group in contrast to general therapy group , but there no significant differences between the two study groups in LVMI , the levels of serum Ca2+, the rates of cardiovascular events and adverse reactions , P >0. 05. Conclusion: Calcitriol might significantly decrease the levels of serum BNP and MMP-9 in patients with CHF.
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