卵巢特异性启动子的研究进展

摘要

卵巢癌在妇科恶性肿瘤中发病率居第三位，病死率居首位，尽管通过手术和化疗后要达到临床和血液生化指标完全缓解，但是多数晚期患者仍会在2～3年内复发，最终结果是化疗耐药死亡。寻找新的卵巢癌治疗方法迫在眉睫。随着分子生物学技术的发展，靶向治疗的研究越来越多，因为肿瘤组织和正常组织之间的差异，通过分子生物技术手段，将药物或者自杀基因靶向导入到肿瘤组织内，而对正常组织无损害。基因的靶向治疗最重要的是将基因转入在体内并在特定的组织内表达，其中最为重要的部分是特异性启动子的作用。文章就启动子的特性，对卵巢特异性启动子的分类及研究进展作综述。%ABSTRACT:Ovarian cancer ranks third in gynecological malignant tumors,but is associated with the highest mortality rate.Although complete clinical and biochemical remission is achieved after initial surgery and chemotherapy,most patients have recurrence within 2-3 years and ultimately die of drug resistance.Therefore,it is urgent to find a new method for the treatment of ovarian cancer.With the development of molecular biological techniques,targeted therapy attracts more attention.Because of the difference between tumor and normal tissues,molecular biological tech-niques can be used to target drugs or suicide genes into tumor tissue with no damage to normal tissue.Gene transfer and expression,especially the role of specific promoter,are most important for targeted gene therapy.This paper reviews the characteristics,classification and research pro-gress of ovarian specific promoter.