40岁以下乳腺浸润性导管癌患者VEGF表达与淋巴结转移关系分析

摘要

目的：观察血管内皮生长因子（ VEGF）在40岁以下乳腺浸润性导管癌患者癌组织表达及与淋巴结转移的关系。方法免疫组化技术检测31例≤40岁乳腺浸润性导管癌（实验组）及同期＞40岁83例乳腺浸润性导管癌（对照组） VEGF的表达情况，观察实验组淋巴结转移数与VEGF表达的关系。结果实验组VEGF表达及淋巴结转移率显著高于对照组（ P ＜0.01）；实验组VEGF蛋白表达率与淋巴结转移数目之间存在显著性差异（ P ＜0.05），随着VEGF蛋白表达升高，淋巴结转移数逐渐增加；实验组有淋巴结转移者较无淋巴结转移者原发灶VEGF的表达明显升高（ P ＜0.05）；实验组原发灶与淋巴结转移灶VEGF表达无显著性差异（ P ＞0.05）。结论 VEGF高表达与40岁以下女性乳腺浸润性导管癌淋巴结转移密切相关，可用于指导乳腺癌的治疗及评估预后。%Objective To investigate the expression of vascular endothelial growth factor ( VEGF) in less than 40 years old women with breast invasive ductal carcinoma and its relationship to lymph node metastasis.Methods The expression of VEGF were detected by immunohistochemistry in 31 cases of experimental group (≤40 years old ) and 83 cases of control group (>40 years old ) , and the relationship between the expression of VEGF and the number of metastatic lymph nodes was also investigated.Results There were higher expression of VEGF and lymph node metastasis rate in experimental group than control group ( P <0.01 ) , and there is statistical significance between expression of VEGF and lymph node metastasis rate in experimental group ( P <0.05 ) , and with the VEGF protein expression increased, the number of lymph node metastasis increased significantly.The positive rate of VEGF in lymph-node-positive group was significantly higher than that in lymph-node-negative group in experimental group ( P <0.05), and their is no statistical significance between lymph node metastasis and primary lesion in experimental group ( P >0.05).Conclu-sion The expression of VEGF is closely related to the lymph node metastasis in breast invasive ductal carcinoma, which might be used to guide breast cancer treatment and assessment of prognosis.