二氢杨梅素对大鼠肾结石抑制作用研究

摘要

The prevention mechanism of dihydromyricerin in Ampelopsis grossedentata on rat kidney stones was studied in the current work.The results showed that the concentrations of BUN or Cr in serum,and Ca or UA in urine were reduced,while SOD activity in renal tissue was increased.MDA content was also decreased by dihydromyricetin.Renal biopsy revealed that the calcium oxalate crystals of rat in dihydromyricetin group were significantly reduced,and the lumen expansion was also decreased.Therefore,dihydromyricetin had a preventive effect on rat kidney stones.%试验研究了藤茶中二氢杨梅素对预防大鼠肾结石的作用机制.结果表明:二氢杨梅素能够降低大鼠血清BUN、Cr和尿中Ca、UA含量,增加肾组织SOD活性,降低MDA含量.肾组织切片显示,二氢杨梅素组草酸钙结晶明显减少,管腔扩张减小,说明二氢杨梅素对大鼠肾结石有一定的防治作用.