CXCL12/CXCR4生物学轴诱导前列腺癌骨转移的作用机制研究进展

摘要

CXCL12(stromal-derived factor-1,SDF-1) and its receptor CXCR4(chemokine (C-X-C motif) receptor 4)were demonstrated to be widely expressed in a broad array of tissues and organs.Recent studies suggested that CXCL12/ CXCR4 axis was related to the adhesion,invasion,proliferation and survival of prostate cancer cells,and played an important role in bone metastasis.Elucidating the relationship between the CXCL12/ CXCR4 axis and the development of bone lesion of prostate cancer is helpful to find a new way to treat the disease.%研究发现趋化因子CXCL12(Stromal-derived factor-1,SDF-1)和受体CXCR4[chemokine (C-X-C motif) receptor 4]广泛表达于组织和器官上,相关的研究发现其与前列腺癌细胞的黏附、侵袭、增殖和生存有关,并认为其在前列腺癌骨转移的发生中发挥重要作用.通过阐明CXCL12/CXCR4生物学轴和前列腺癌骨转移之间的关系,从而寻找有助于疾病治疗的新途径.