目的:了解心包原发性恶性间皮瘤(primary malignant pericardial mesothelioma,PMPM)的临床病理特点.方法:收集2例PMPM患者的临床资料.切除组织HE染色光镜观察,免疫组织化学做 CKp、CK18、EMA、MC、Vimentin、CEA、Calretinin、TTF1、Tg 标记.结果:2例 PMPM是以上皮细胞为主型,呈乳头状和腺管样排列.免疫组织化学标记瘤组织CKp、CK18、Vimentin、Calretinin阳性.MC 例1阳性,例2阴性,EMA 例1阴性,例2阳性.临床改变似心包炎和心包积液.结论:恶性心包间皮瘤临床改变似心包炎,只有病理检查才能确诊.%Objective: To investigate the clinicopathological features of primary malignant pericardial mesothelioma. Methods: By means of histological, and immunohistochemical studies, the clinical and pathological features oi two cases of primary pericardial malignant mesothelioma were analyzed. Results: Patients of two cases were 38 and 60 years old. The tumors were located in the pericardial, and involved the wall of pericardial. Immunohistochemical expression of cytokeratin AE1/AE3 ,cytokeratin 18,Vimentin, epithelial membrane antigen, Calxetinin were positive in both cases, mesothelial cell was positive in case 1 and negative in case 2. Conclusion: Primary malignant pericardial mesothelioma is a rare tumor. The diagnosis was based on histological and immunohistochemical staining.
展开▼
