伊立替康联合顺铂在局部晚期宫颈癌同步放化疗中的近期疗效观察

摘要

Objective:To evaluate the short - term curative effect and side effects of concurrent chemoradiotherapy plus irinotecan - based cisplatin in locally advanced cervical cancer. Methods: During May 2011 to December 2011, 21 cases of clinical Ⅱh - Ⅳa cervical cancer patients had been undergone the chemoradiation of 3D - CRT plus irino-tecan - based cisplatin. Results; The general effective rate was 90.5% (19/21) after 4 weeks treatment. Among them CR 15 cases, PR 4 cases, SD 2 cases and PD 0 case. Bone marrow suppression was the main toxic reaction, Ⅲ - IV level leukopenia was 57.1% (12/21). Ⅲ - Ⅳ level thrombocytopenia was 33% (7/21) , Ⅲ - Ⅳ level diar-rhea 19% (4/21) , without any lethal complication. Conclusion; The short - term curative effect of concurrent che-moradiotherapy plus irinotecan - based cisplatin in locally advanced cervical cancer was satisfied, but the complica-tions should be paid special attention to, especially bone marrow suppression and diarrhea,should actively be given symptomatic treatment.%目的:评价伊立替康联合顺铂在局部晚期宫颈癌同步放化疗中的近期疗效及毒副作用.方法:2011年5月-2011年12月收治的Ⅱb-Ⅳa期宫颈癌患者21例,在行三维适型放疗过程中予以伊立替康联合顺铂同步放化疗.结果:治疗结束后4周总的有效率为90.5％(19/21).其中CR 15例、PR 4例、SD 2例、PD 0例.毒性反应以骨髓抑制为主,Ⅲ-Ⅳ级白细胞下降为57.1％(12/21).Ⅲ-Ⅳ度血小板下降为33％(7/21).Ⅲ-Ⅳ级腹泻19％(4/21)无致死性并发症发生.结论:在局部晚期宫颈癌同步放化疗过程中应用伊立替康近期疗效满意,但应特别注意骨髓抑制及腹泻等并发症,应积极给予对症处理.