结直肠癌患者血清UGT1 A8、CA19-9、CEA联合检测对早期临床诊断的指导价值

摘要

Objective;To study the diagnostic value and clinical significance for rectal cancer with determination of serum UGT,CEA and CA19 -9. Methods: Fourty colorectal cancer serum and thirty healthy person serum were determinated by enzyme linked immunosorbent assay ( ELISA). Results:CEA was distinctly increased in the colorectal cancer serum than in the healthy contrast group serum (P <0. 01 ) , CA19 -9 was increased (P <0. 05). However, UGT was distinctly lower in the colorectal cancer serum than in the healthy contrast group serum( P <0.01). Conclusion :Combined detection of CEA,CA19 -9 and UGT1 A8 is useful for the diagnosis of colon rectal cancer.%目的:探讨血清CA19-9、CEA、UGT联合检测对消化道肿瘤结肠癌的诊断价值及其临床意义.方法:取患者清晨空腹外周静脉血,分离血清,用化学发光法检测肿瘤标记物CEA,CA19-9酶联免疫法检测UGT1 A8.结果:结l直肠癌患者血清CEA检测值明显升高,与正常对照组相比有显著差异,P＜0.Ol,CA19-9检测值也升高,与正常对照组相比也有明显差异,P＜0.05,而结肠癌患者血清UGT1 A8检测水平却明显降低,P＜0.01.结论:UGTIA8、CEA和CA19-9联合检测可提高肿瘤诊断的准确率.