PT、APTT、FBG、PLT测定在食管癌、胃癌、直肠癌患者中的临床意义

摘要

Objective:To study the changes of three coagulation parameters and blood platelets count in patients with esophageal carcinoma, astric carcinoma and rectal cancer and its clinical significance. Methods; PLT, PT, APTT,TT,FBC levels of 99 normal individuals and 185 esophageal carcinoma,astric carcinoma and rectal cancer patients (56 esophageal carcinoma patients,60 gastric carcinoma patients,69 rectal cancer patients) were examined by CA7000 and XE2100. Results: As compared with normal persons PT,APTT,FBG and PLT were significantly different in esophageal carcinoma gastric carcinoma and rectal cancer patients ( P <0.05). In different period of esophageal carcinoma gastric,carcinoma and rectal cancer patients, PT, APTT.FBG and PLT were higher than normal persons (P <0.05). In different period of esophageal carcinoma gastric carcinoma and rectal cancer patients FBG was higher (P <0.05) , while PT. Conclusion; The higher of FBG and PLT indicate that blood hypercoagulabale state exists in esophageal carcinoma gastric carcinoma and rectal cancer patients. The prolongation of PT,APTT,TT in blood plasma indacate that esophageal carcinoma gastric carcinoma and rectal cancer patients have alimentary tract hemorrhage tendency. The detection of PT,APTT,TT,FBG and PLT may play a specific role in the laboratory examination of e-sophageal carcinoma gastric carcinoma and rectal cancer patients.%目的:研究食管癌、胃癌、直肠癌患者三项凝血指标及血小板计数的变化及临床意义.方法:采用CA7000全自动血凝分析仪和XE2100全自动血液分析仪测定185例患者的血小板计数(PLT)、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原(FBG)水平,并与99例健康体检者进行比较.结果:食管癌、胃癌、直肠癌组患者血浆PT、APTT、FBG水平与PLT计数较健康对照组相比有明显的增高,且差异具有统计学意义(P＜0.05)；患者早期观察组血浆PT、APTT、FBG水平与PLT计数较健康对照组有明显的增高,且差异具有统计学意义(P＜0.05)；食管癌、胃癌、直肠癌患者中晚期观察组血浆FBG水平较早期观察组有明显的增高(P＜0.05)；食管癌、胃癌、直肠癌患者中晚期观察组血浆PT、APTT水平与PLT计数与早期观察组相比有增高的倾向,但差异无统计学意义(P＞0.05).健康对照组、食管癌、胃癌、直肠癌患者早期观察组和中晚期观察组三组观察对象间血浆PT、APTT、FBG水平和PLT计数有差异,且差异具有统计学意义(P＜0.05).结论:食管癌、胃癌、直肠癌患者血浆FBG水平和PLT计数增高表明其存在血液的高凝状态,其血浆PT、APTT延长表明食管癌、胃癌、直肠癌患者有并发消化道出血的倾向.在临床中对食管癌、胃癌、直肠癌患者血浆PT、APTT、FBG水平和PLT计数进行检测,有助于为血栓形成和消化道出血的诊断提供相应的实验室检查依据,也可为临床中此类指标出现异常的患者是否需行抗凝和止血治疗提供参考.