CCND1基因G870 A位点多态性与宫颈癌易感性的Meta分析

摘要

目的：运用Meta分析方法研究CCND1基因G870A位点多态性与宫颈癌易感性的发生风险。方法：检索PubMed和CNKI数据库中有关CCND1基因G870A位点多态性与宫颈癌易感性的相关性研究，根据纳入标准提取文献数据，应用STATA 11.0软件以OR值和95%可信区间为效应指标，进行Meta统计分析，并对发表偏倚及检测敏感性进行检测。结果：纳入9篇对照研究，共计2638例宫颈癌患者和3651例健康对照人群，Meta分析结果显示，总人群中，CCND1基因G870A位点多态性与宫颈癌风险之间没有显著关联（ GA vs GG：OR=1.07，95%CI=0.86-1.34，p=0.53，I2=57.6%；AA vs GG：OR =1.09，95%CI=0.79-1.51，p=0.59，I2=75.0%；（ GA+AA）vs GG：OR=1.08，95%CI=0.86-1.36，p=0.49，I2=64.6%；AA vs（ GG+GA）：OR=1.07，95%CI=0.83-1.36，p=0.61，I2=73.3%）。在针对种族和对照人群来源设计的亚组分析中，仍没有发现CCND1基因G870A位点多态性和宫颈癌的发生风险具有相关性。结论：CCND1基因G870A位点多态性可能与宫颈癌的发生无关。%Objective:To investigate the association between CCND1 G870A polymorphism and cervical cancer risk by using Meta-analysis. Methods:The relevant literatures were searched. The data of genotype distributions and other information were extracted in the groups of patients and healthy control,Odds ratio( OR)with 95% confidence interval(CI),publish bias and sensitive analysis was perfoymed with STATA 11. 0 software. Results:Nine published case-control studies were selected,including 2638 patients with cervical cancer and 3651 controls. Overall,no signif-icant association between CCND1 G870A polymorphism and cervical cancer risk was found in this Meta -analysis (GA vs GG:OR=1. 07,95%CI=0. 86-1. 34,p=0. 53,I2 =57. 6%;AA vs GG:OR=1. 09,95%CI=0. 79-1. 51, p=0. 59,I2 =75. 0%;(GA+AA)vs GG:OR=1. 08,95%CI=0. 86-1. 36,p=0. 49,I2 =64. 6%;AA vs(GG+GA):OR=1. 07,95%CI=0. 83-1. 36,p=0. 61,I2 =73. 3%). In the subgroup analysis ethnicity and study de-sign,no significant association was detected in other genetic models. Conclusion:This Meta-analysis demonstrates that CCND1 G870A polymorphism may be not a risk factor for cervical cancer.