血清HO－1、CA72－4、SCC－Ag联合检测在食管鳞癌诊断中的价值

摘要

目的:探讨血清血红素氧合酶1(HO－1)、糖类抗原CA72－4、鳞状细胞癌抗原(SCC－Ag)联合检测对食管鳞癌的诊断价值.方法:纳入收治的食管鳞癌患者126例为观察组,选取同期来院进行体检的健康人员45例为正常对照组.两组人员入组第二天清晨采集腹静脉血4 ml,分离血清后进行HO－1、CA72－4、SCC－Ag检测.对比正常对照组和观察组患者血清HO－1、CA72－4、SCC－Ag的阳性检测率;分析血清HO－1、CA72－4、SCC－Ag含量变化与食管鳞癌临床分期的相关性;对比HO－1、CA72－4、SCC－Ag单独及联合检测在食管鳞癌患者中的阳性率.结果:血清HO－1、CA72－4、SCC－Ag在食管鳞癌患者中的阳性率和对照组比较明显较高,差异有统计学意义(P＜0.05).血清HO－1、CA72－4、SCC－Ag检测在食管鳞癌患者中的阳 性率随临床分期升高而升高,血清HO－1、CA72－4、SCC－Ag检测在食管鳞癌Ⅲ期患者中的阳性率和Ⅰ期、Ⅱ期比较明显较高,差异有统计学意义(P＜0.05).HO－1、CA72－4、SCC－Ag其中任何两项检测食管鳞癌的阳性率与任何一项单独检测比较明显较高(P＜0.05);HO－1、CA72－4、SCC－Ag三项联合检测食管鳞癌的阳性率与任何单项、双项检测比较明显较高,差异有统计学意义(P＜0.05).结论:血清HO－1、CA72－4、SCC－Ag三项指标联合检测可明显提高食管鳞癌的诊断阳性率,弥补了单项指标检测的不足,降低了漏检率,为食管鳞癌诊断和鉴别诊断提供了有力的参考依据.%Objective:To investigate the value of combined detection of serum heme oxygenase 1(HO－1),carbo-hydrate antigen(CA72－4)and squamous cell carcinoma antigen(SCC－Ag)in the diagnosis of esophageal squa-mous cell carcinoma.Methods:One hundred twenty－six esophageal squamous cell carcinoma patients who admitted in our hospital were included into the observation group,and another 45 healthy person who received physical exami-nation in our hospital during the same period were selected and included into the normal control group.Next morning after enrolled into groups,4 ml venous blood were collected from patients in two groups,and the detection of HO－1,CA72－4 and SCC－Ag was conducted after separation of serum.The positive detection rates of serum HO－1,CA72－4 and SCC－Ag of two groups were compared.The correlation between the content of HO－1,CA72－4 and SCC－Ag and the clinical stage of esophageal squamous cell carcinoma was analyzed.And the positive rates of single detec-tion and combined detection of HO－1,CA72－4 and SCC－Ag in esophageal squamous cell carcinoma were com-pared.Results:The positive rate of serum HO－1,CA72 －4 and SCC－Ag in esophageal squamous cell carcinoma patients of the observation group were higher than those in the control group,and the differences were statistically sig-nificantly(P＜0.05).The positive rate of serum HO－1,CA72－4 and SCC－Ag in esophageal squamous cell carci-noma patients were increased with the increasing of clinical stage of esophageal squamous cell carcinoma,and the pos-itive rate of HO－1,CA72－4 and SCC－Ag in stage Ⅲ esophageal squamous cell carcinoma patients were signifi-cantly higher than those in stage Ⅰ and stage Ⅱ esophageal squamous cell carcinoma patients,and the differences were statistically significant(P＜0.05).The positive rate of combined detection of any two of HO－1,CA72－4 and SCC－Ag was significantly higher than the single detection of any one(P＜0.05).The positive rate of combined detection of HO－1,CA72－4 and SCC－Ag was significantly higher than that of single detection and combined detection of any two of them(P＜0.05).Conclusion:The combined detection of serum HO－1,CA72－4 and SCC－Ag can sig-nificantly improve the diagnosis positive rate of esophageal squamous cell carcinoma,make up the deficiency of single index detection,reduce the rate of missed detection,and provide a strong reference basis for the diagnosis and differ-ential diagnosis of esophageal squamous cell carcinoma.