Objective:To systematically evaluate the efficacy and safety of elemene in the treatment of malignant pleural effusion of lung cancer. Methods:The databases of PubMed,Cochrane Library,EMbase,SCI,Chinese Aca-demic Journal Full Database,and Chinese Biomedical Literature Database were searched from the establishment of the library to March 2017. Randomized controlled studies on the efficacy and safety of elemene in the treatment of malig-nant pleural effusion of lung cancer were included. The quality of the included studies was evaluated using the quality evaluation criteria of the Cochrane Handbook version 5. 1. 0,and the Review Manager 5. 3 software was used for data analysis. Results:A total of 15 articles were included,and including 1004 patients. Results of Meta - analysis showed that elemene significantly improved the short term efficacy of malignant pleural effusion(RR = 1. 36,95% CI:1. 15 ~1. 60,P = 0. 0003). Subgroup results showed that the effective rate of elemene in the treatment of malignant pleural effusion was significantly higher than that of the cisplatin group(RR = 1. 46,95% CI:1. 14 ~ 1. 87,P = 0. 003). Meanwhile,elemene did not significantly increase the incidence of chest pain and fever and other adverse reactions(P> 0. 05). Conclusion:Intrapleural injection of elemene can improve the treatment efficiency of malignant pleural effu-sion with good safety in lung cancer. However,due to the poor quality of the included studies,the conclusion still needs to be confirmed by more large sample randomized controlled trials.%目的:系统评价榄香烯治疗肺癌恶性胸腔积液的疗效及安全性.方法:计算机检索PubMed、Co-chrane Library、EMbase、SCI、中国学术期刊全文数据库、中国生物医学文献数据库等数据库,搜索年限从建库到2017年3月.纳入榄香烯治疗肺癌恶性胸腔积液疗效与安全性方面的随机对照研究.使用Cochrane手册5.1.0版的质量评价标准对纳入研究进行质量评价,使用Review Manager 5.3软件进行数据分析.结果:共纳入15篇文章,包含1004例患者.Meta分析结果表明榄香烯可显著提高恶性胸腔积液患者近期治疗疗效(RR=1.36,95%CI:1.15~1.60,P=0.0003).亚组结果表明,榄香烯治疗恶性胸腔积液的有效率显著高于顺铂组(RR=1.46,95%CI:1.14~1.87,P=0.003).榄香烯并不显著增加胸痛及发热等不良反应的发生(P>0.05).结论:胸腔内注射榄香烯可提高肺癌恶性胸腔积液治疗有效率,安全性良好.由于纳入研究的质量欠佳,该结论仍需大样本随机对照试验进一步证实.
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