肾脏脂肪囊多形性脂肪肉瘤1例报告并文献复习

摘要

目的:探讨肾脏脂肪囊多形性脂肪肉瘤的的临床特点、病理特点、诊治方法及预后.方法:报告1例肾脏脂肪囊多形性脂肪肉瘤患者的临床资料,结合相关文献复习并讨论.结果:患者,男,67岁.因影像学发现右肾区占位入院,接受腹腔镜下右肾根治性切除术,病理诊断为肾脏脂肪囊多形性脂肪肉瘤,免疫组化染色显示S-100(弱+),MDM2(+),CDK4(+),CD10(+),muscle(-),CK(-).术后随访17个月无原位复发及远处转移.结论:肾脏脂肪囊多形性脂肪肉瘤临床罕见,具有高度恶性和侵袭性,易复发及转移,预后较差.确诊需依靠影像学及病理免疫组化检查,手术完整切除肿瘤是目前有效的治疗方法.%Objective:To investigate the clinical characteristics,pathological features,diagnosis,treatment,and prognosis of pleomorphic liposarcoma of renal adipose capsule.Methods:The clinical data of a patient with pleomorphic liposarcoma of renal adipose capsule were reported,and related literatures were reviewed.Results:A 67-year-old male patient was diagnosed as having renal neoplasm by imageological examination.The patient underwent laparoscopic radical nephrectomy on right kidney.Pathological diagnosis showed the pleomorphic liposarcoma of renal adipose capsule.Immunohistochemical stain showed positive results for S-100,MDM2,CDK4 and CD10,while negative for muscle and CK.The patient was followed-up for 17 months,and no recurrence or metastasis was observed.Conclusions:Pleomorphic liposarcoma of renal adipose capsule is rarely seen clinically.It is an aggressive,high grade neoplasm with a tendency for recurrence and metastases and often carries a poor prognosis.The definite diagnosis mainly depends on imageological examination and immunohistochemical stain.A complete resection surgery is the best treatment method.