P-糖蛋白与P53蛋白在乳腺癌中的表达及意义

摘要

Objective To investigate the expression of P-glycoprotein (P-gp) and P53 protein in breast cancer and the significance. Methods Tumor samples from 53 patients with breast cancer, receiving no chemotherapy before surgery, were fixed in formalin and em-bedded with paraffin, and then the expression of P-gp and P53 protein was detected by immunohistochemistry. Results The expression of P-gp and P53 protein in breast cancer reached 49%(26/53) ad 51%(27/53) respectively;the expression of P-gp was not correlated with the age of the patients, histological types and lymph node metastasis (P>0.05) while the expression of P53 protein was not correlat-ed with the histological types and lymph node metastasis (P>0.05)but with the age of the patients (P<0.05);the expression of P-gp in P53 positive cases was much higher than that in P53 negative cases (P<0.01). Conclusions The detection of the expressions of P-gp and P53 protein by immunohistochemistry is of certain clinical value in evaluating the effect of chemotherapy for breast cancer and the prog-nosis.%目的：探讨P糖蛋白（P-gp）和P53蛋白在乳腺癌中的表达及意义。方法53例术前未进行化疗的乳腺癌标本经福尔马林固定、石蜡包埋后，用免疫组织化学方法检测乳腺癌组织中的多药耐药蛋白P-gp和P53的表达情况。结果 P-gp和P53在乳腺癌中的表达分别为49%（26/53）和51%（27/53）。P-gp表达与乳腺癌患者的年龄、组织学类型和淋巴结转移状况无关（P＞0.05），而P53蛋白的表达除与年龄有关外（P＜0.05），与组织学类型和淋巴结转移无关（P＞0.05），P-gp在P53阳性病例中的表达明显高于P53阴性者（P＜0.01）。结论免疫组织化学法检测P-gp、P53蛋白的表达对评估和指导乳腺癌化疗及预后具有一定的临床价值。