To characterize the risk factors and coronary artery lesion in patients with premature coronary artery disease ( PCAD) between genders. Methods A total of 270 patients diagnosed by coronary angiography were divided into male group ( < 55years,n = 158) and female group( <65years,n = 112). We collected the cardiovascular risk factors (hypertension, diabetes, family history of premature coronary artery disease, smoking, dyslipidemia, body mass index,etc) , blood parameters( cholesterol,total bilirubin,u-ric acid,fibrinogen,CRP) and coronary artery features for statistical analysis. Results Smoking was more prevalent among men (73.4% vs 1.8% ,P <0.001) . There were no significant diferences in the prevalence of hypertension, diabetes, family history, obesity,and dys-lipidemia( P > 0. 05). The male group had higher level of bilirubin uric acid, lower levels of blood HDL - C and Apoa (P < 0. 05). There was no significant difference in hyperuricemia between the two groups (P > 0. 05). There was significant difference in the low density lipo-protein hyperlipidemia( P < 0. 05). There was a higher incidence of slow flow and long lesions with coronary artery in the male group who had a higher Gensini point( P <0. 05 ). Conclusion The coronary artery lesion in males is less than that in females, because of the dyslipidemia and low coronary protection caused by smoking.%目的 探讨不同性别早发冠心病(PCAD)患者的心血管危险因素和冠状动脉病变的特征.方法 共入选经冠脉造影确诊为PCAD患者270例,分为男性组158例和女性组112例,对两组常见心血管危险因素(高血压史、糖尿病史、PCAD家族史、吸烟史、血脂异常病史、体重指数等)、血液指标(血脂、尿酸、纤维蛋白原、C反应蛋白等)和冠状动脉病变特征进行分析.结果 男性组吸烟比例显著高于女性组(73.4％ vs l.8％,P＜0.001),两组间高血压、糖尿病、PCAD家族史、肥胖、血脂异常病史无统计学差异(P＞0.05),男性组血尿酸水平高于女性组(P＜0.05),高密度脂蛋白胆固醇和Apoa水平低于女性组(P＜0.05),但高尿酸血症两组间无统计学差异(P＞0.05),低高密度脂蛋白血症在两组间存在统计学差异(P＜0.05).男性组冠脉慢血流、长病变发生率高于女性组(P＜0.05),Gensini冠脉积分高于女性组(P＜0.05).结论 男性PCAD患者冠脉病变严重程度高于女性,与吸烟以及吸烟所致血脂代谢紊乱、冠脉保护机制降低有关.
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