老年高血压患者危险程度分级与血脂、血尿酸水平关系分析

摘要

Objective To investigate the relationship between the severity of hypertension and the level of blood lipid and serum uric acid (SUA) in elderly hypertensive patients.Methods Totally 178 cases of elderly hypertensive patients were selected.According to the degree of hypertension risk classification they were divided into moderate risk group of 70 cases,high risk group of 73 cases,very high risk group of 35 cases,control group of 80 cases.We recorded height,weight,whether smoking,whether drinking,whether there is abnormal ECG,blood pressure in four groups.The four groups of SUA,fasting blood glucose and blood lipid were measured by automatic biochemical instrumentation,and the differences of the four indexes were compared.Results There were no significant differences in age,sex,smoking,whether drinking and BMI (P ＞ 0.05).The control group was TC (4.85 ± 0.89mmol/L),which was significantly higher than that of the middle risk group(4.45 ± 0.94mmol/L),high risk group(4.49 ± 1.l8mmol/L) and extremely high risk group(4.40 ±1.14mmol/L,P ＜ 0.05).The HDL-C of the medium risk group and the extremely high risk group (1.09 ± 0.32mmol/L,1.11 ±0.30mmol/L,0.96 ±0.22mmol/L),were significantly lower than those of the control group (1.20 ±0.33mmol/L,P ＜ 0.05).The high risk group of SUA for (439 ± 115μmol/L),higher than that of the control group (319 ±78μ mol/L),risk group (325 ± 101μmoL/L)and high-risk group (337 ± 1108μmol/L,P ＜ 0.05).Moderate and high-risk group compared with control group,it was not significant (P ＞0.05).The GLU in the control group was (6.01 ± 1.60mmol/L),significantly lower than that in the high-risk group (7.18 ±2.93mmol/L) and extremely high risk group (8.38 ± 3.01mmol/L,P ＜ 0.05).Insulin resistance and high uric acid was correlated with high blood pressure risk classification (P ＜ 0.05).Conclusion With the increase of high blood pressure risk classification,insulin resistance and high uric acid hematic disease gradually increase.Serum uric acid level can be used as judgment hypertension a dangerous level.%目的 探讨老年高血压患者危险程度分级与血脂、血尿酸水平的关系.方法 选取老年高血压患者178例,按高血压危险程度分级分为中度危险组70例,高度危险组73例,极高度危险组35组,对照组选取健康体检人群80例,记录身高、体重、是否吸烟、是否饮酒、是否存在异常心电图,测量4组的血压.用全自动生化仪器检测4组的SUA、空腹血糖及血脂全套指标,比较4组各项指标的差别.结果 4组患者在年龄、性别、是否吸烟、是否饮酒及体重指数(BMI)4个方面差异无统计学意义(P＞0.05);对照组TC为4.85±0.89mmol/L,明显高于中危组(4.45±0.94mmol/L)、高危组(4.49±1.18 mmol/L)及极高危组(4.40±1.14mmol/L,P＜0.05);中危组、高危组、极高危组HDL-C分别为1.09±0.32mmoL/L、1.11±0.30mmol/L、0.96±0.22mmoL/L,明显低于对照组(1.20±0.33mmol/L,P＜0.05);极高危组SUA为439± 115μmol/L,高于对照组(319±78 μmol/L)、中危组(325±101 μmol/L)及高危组(337±1108 μmol/L,P＜0.05),中危组、高危组与对照组比较差异无统计学意义(P＞0.05);对照组GLU为6.01±1.60mmol/L,明显低于高危组(7.18±2.93mmol/L)及极高危组(8.38 ±3.01 mmol/L,D＜0.05);HDL-C与高血压的危险程度呈负相关,血尿酸水平均与高血压的危险程度均呈正相关(P＜0.05).结论 随着高血压危险程度的升高,血脂及血尿酸水平逐步升高,可作为判断高血压危险程度的指标.