绿茶多酚对东莨菪碱及D-乳糖所致小鼠学习记忆障碍的影响

摘要

Objective To investigate the improvement of Green tea polyphenols in the memory acquisition im-pairment of mice .Methods Memory acquisition impairment model in mice with the method of scopolamine intrap-eritoneal injection was made .D-galactose of 140mg/kg was intraperitoneally injected into mice to establish learning behaviour obstructed mice model .The step-down and water maze were used as evaluation indexes ,and the effects of different dosages Green tea polyphenols on mouse learning dysmnesia were observed .Results Among scopolam-ine and D-galactose-induced mouse dysmnesia models ,Green tea polyphenols could decrease the number of errors in the step down test ( P<0.05 ) ,and prolonged the latency significantly ( P<0.01 ) .In the water maze test ,Green tea polyphenols could decrease the mistaken reaction times ( P<0.05 or P<0.01 ) ,and shorten the incubation pe-riod .Conclusion Green tea polyphenols have the improvement in the memory acquisition impairment of mice in-duced by scopolamine .and D-galactose .%目的：研究绿茶多酚（green tea polyphenols ，GTPs）对记忆障碍模型小鼠学习记忆功能的影响。方法以东莨菪碱和D-半乳糖复制记忆障碍小鼠模型，以跳台和水迷宫为学习记忆指标，观察不同剂量的GTPs对小鼠学习记忆的影响。结果在东莨菪碱和D-半乳糖记忆障碍小鼠模型中，与模型组比较，GTPs能减少小鼠在跳台实验中的错误次数（P＜0．05），延长跳台潜伏期（P＜0．01），GTPs可缩短小鼠在水迷宫实验中的潜伏期（P＜0．05），减少错误次数（P＜0．05）。结论 GTPs对东莨菪碱及D-半乳糖造成的两种学习记忆获得障碍小鼠的学习记忆能力均有明显的改善作用。