5-羟色胺1 A 受体及其二聚化研究进展

摘要

5-羟色胺1 A（5-HT1 A）受体是典型的视紫红质样 G 蛋白偶联受体（GPCRS），广泛分布于脑组织中，与多种精神类疾病的发病机制密切相关，是精神类疾病（抑郁症、慢性疼痛等）治疗的重要药物靶点。以往的研究集中于5-HT1 A 受体单体，近来研究发现，5-HT1 A 受体还能以二聚体的形式存在并发挥其独特的生理、药理作用。本文就5-HT1 A 受体与多种 G 蛋白偶联受体所形成的二聚体，以及二聚化之后对相关疾病产生的作用做一简要综述，为与5-HT1 A 受体相关精神疾病的研究提供新的理论基础，为药物研发提供新的靶点。%Objective 5-hydroxytryptamine 1 A receptor (5-HT1 AR),a typical rhodopsin-like G protein-coupled receptor (GPCR)is widely distributed in the brain tissue.5-HT1 AR is closely related to the patho-genesis of mental illness such as depression and chronic pain which is important targets for the treatment of neurological and mental diseases.In previous studies 5-HT1 AR monomer were focused.However,recent stud-ies show that 5-HT1 AR also exerts its physiological functions in the form of dimer.In this review,we summa-rize a brief overview about 5-HT1 AR and its a variety of dimers with other GPCRS.Meanwhile,the impact of its dimers on the related diseases was also introduced which provide a new theoretical basis for treatment with 5-HT1 AR related mental disorders and a new potential target for drug development.