抑郁症的病因尚不清楚,但目前普遍认为5-羟色胺(5-HT)系统活性降低是导致抑郁症的一大原因.通过增加5-HT能神经递质的方式可以达到缓解抑郁症症状的目的,而其受体异常可能是抑郁症发病的重要风险因素之一.其中,5-HT1A自受体和异受体在5-HT的传递中发挥不同的作用,对调节5-HT相关的抗抑郁作用至关重要.因此,5-HT1A受体的转录调控可能成为未来的新靶点,不仅可为筛选危险人群、早期诊断、早期干预及个体化治疗提供理论依据,还能为新型抗抑郁药物的研发提供新思路.%The pathogenesis of depression is not clear,but it is generally accepted that decreased activity of 5-hydro-xytryptamine(5-HT)system is a major cause of depression.Increasing 5-HT neurotransmitter can achieve the purpose of alleviating the symptoms of depression,and its receptors abnormalities may be one of the important risk factors for major depressive disorder.Among them,5-HT1Aautoreceptors and heteroreceptors play different roles in the 5-HT transmission, which is crucial to regulating 5-HT related antidepressant effect.Therefore,the transcriptional regulation of 5-HT1Areceptor may be a new target in the future.It not only provides a theoretical basis for screening population at higher risk,early diag-nosis,early intervention and individualized treatment,but also provides new ideas for the development of new antidepres-sants.
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