髓性白血病的免疫调节和细胞免疫治疗研究进展

摘要

T cell immune status is critic for maintaining anti-leukemia effect in leukemia patients.In patients with myeloid leukemia,T cell function becomes suppressed with disease progression.Several im-munotherapies have been developed for myeloid leukemia in different stages and relapse after allogeneic stem cell transplantation.In this review,several specific immunotherapeutic approaches for myeloid leu-kemia,including adoptive cellular immunotherapy and potential immunoregulation therapy are summa-rized.%T细胞免疫状态与白血病病人抗白血病效应息息相关，在髓性白血病中，随着病情进展T细胞功能抑制更为明显。近年来，对于不同疾病不同阶段以及同种异型造血干细胞移植后复发病人，已形成了一些免疫治疗的新措施。本文主要介绍新近一些针对髓性白血病的特异免疫治疗包括过继性细胞免疫治疗以及可能的免疫调节治疗的研究进展。