Ck2α、β-catenin和survivin在卵巢癌组织中表达的检测及其临床应用价值

摘要

Objective To study the expressions of casein kinase 2α(Ck2α),β-catenin, survivin in ovarian cancer tissue and analyze the relationships between them, and to explore the clinical application value. Methods Immunohistochemistry staining was used to detect the expressions of Ck2α,β-catenin and survivin in 8 cases of simple ovarian cysts tissue,8 cases of ovarian benign tumor tissue and 29 cases of ovarian cancer tissue;the correlations of the expressions of Ck2α,β-catenin,survivin in ovarian cancer tissue and their associations with the clinicopathologic characteristics were analyzed.Results The expression levels of Ck2α,β-catenin and survivin in ovarian cancer tissue were significantly higher than those in simple ovarian cysts tissue and ovarian benign tumor tissue(P<0.05);the Ck2αexpression level in ovarian cancer tissue was positively corelated with the expression levels ofβ-catenin and survivin(r=0.438,r=0.479,P<0.05);the expression levels of Ck2α,β-catenin and survivin in low-medium differentiation group were significantly higher than those in high differentiation group (P<0.05);the expression levels of Ck2α,β-catenin and survivin in stagesⅡandⅢ group were significantly higher than those in stage Ⅰ group(P<0.05).Conclusion The protein expression levels of Ck2α,β-catenin and survivin are increased in ovarian cancer tissue, and three are positive corelations between them;Ck2α,β-catenin and survivin may play an important role in the occurrence and development of ovarian cancer;the combined detection of them has important clinical value.%目的：研究酪蛋白激酶2α（Ck2α）、β-catenin和 survivin在卵巢癌组织中的表达情况，分析三者在卵巢癌中表达的相关性，探讨其临床应用价值。方法：采用免疫组织化学法检测8例卵巢单纯性囊肿组织、8例卵巢良性肿瘤组织和29例卵巢癌组织中Ck2α、β-catenin和 survivin的表达情况，分析3种蛋白在卵巢癌中表达的相关性及与患者临床病理特征的关系。结果：与卵巢单纯性囊肿和良性卵巢肿瘤组织比较，卵巢癌组织中 Ck2α、β-catenin和 survivin蛋白表达水平明显升高（P＜0.05）；卵巢癌组织中 Ck2α与β-catenin和 survivin表达水平呈正相关关系（r＝0.438和r＝0.479，P＜0.05）；在不同分化程度卵巢癌组织中，与低-中分化组比较，高分化组Ck2α、β-catenin和 survivin蛋白阳性表达率明显降低（P＜0.05）；不同 FIGO分期中，与Ⅰ期组比较，Ⅱ期组和Ⅲ期组 Ck2α、β-catenin 和 survivin 蛋白阳性表达率升高，3组间比较差异有统计学意义（P＜0.05）。结论：Ck2α、β-catenin和 survivin在卵巢癌组织中的蛋白表达水平增加，且三者呈正相关，可能与卵巢癌的发生发展有关；Ck2α、β-catenin和 survivin三者联合检测具有重要的临床应用价值。