Ck2α、β-catenin、c-IAP1及 survivin 联合检测在宫颈癌诊断中的临床意义

摘要

Objective To study the expressions and correlations of casein kinase2α (Ck2α), β-catenin, c-in-hibitor of apoptosis protein1 (c-IAP1) and survivin in cervical cancer tissues and to analyze the clinical value of com-bined detection in diagnosis of cervical cancer. Methods A total of 74 patients with cervical cancer (CC group), 83 patients with cervical intraepithelial neoplasia (CIN group) and 50 women with vterine fibroids (control group) were re-cruited in this study. Immunohistochemistry staining was used to detect the Ck2α, β-catenin, c-IAP1 and survivin ex-pressions in the three groups, and the correlations and clinicopathological characteristics were also analyzed. Results The positive expression rates of Ck2α, β-catenin, c-IAP1 and survivin in CC group were significantly higher than those in CIN and control groups, and the expression levels were related with differential degrees of neoplasm and FIGO stages (P < 0. 05). In CC group, the positive expression rate of Ck2α was positively correlated with the expression levels of β-catenin, c-IAP1 and survivin (r = 0. 570, 0. 391, 0. 476, P < 0. 05), and the positive expression rates of Ck2α, β-cate-nin, c-IAP1 and survivin were negatively correlated with differential degrees ( r = - 0. 325, - 0. 633, - 0. 397, -0. 324, P < 0. 05), but the rates were positively correlated with FIGO stages (r = 0. 349, 0. 634, 0. 621, 0. 391, P <0. 05). Conclusion The Ck2α, β-catenin, c-IAP1 and survivin have high positive expression rates in cervical cancer tissues, and the rate are correlated with the occurrence and development of cervical cancer, therefore the combined detec-tion has important clinical value in early diagnosis of cervical cancer.%目的：研究酪蛋白激酶2α(Ck2α)、β-连环蛋白(β-catenin)、凋亡抑制蛋白(c-IAP1)及存活素(sur-vivin)在宫颈癌组织中的表达情况及其相关性,探讨四者联合检测在宫颈癌诊断中的临床意义。方法选择重庆市大足区人民医院收治的宫颈癌74例(宫颈癌组)、宫颈上皮内瘤变(CIN)83例(CIN 组)和子宫肌瘤50例(对照组),采用免疫组化法检测3组宫颈组织中 Ck2α、β-catenin、c-IAP1及 survivin 表达情况,分析其相关性及与临床病理特征的关系。结果宫颈癌组 Ck2α、β-catenin、c-IAP1、survivin 阳性表达率高于 CIN 组和对照组,且其表达与肿瘤分化程度及 FIGO 分期有关( P <0．05),Ck2α阳性表达率与β-catenin、c-IAP1、survivin 表达水平均呈正相关( r =0.570、0．391、0.476,P <0．05),Ck2α、β-catenin、c-IAP1、survivin 阳性表达率与分化程度呈负相关(r =-0.325、-0.633、-0．397、-0.324,P <0．05),与 FIGO 分期呈正相关(r =0.349、0.634、0.621、0.391,P <0．05)。结论 Ck2α、β-catenin、c-IAP1及 survivin 在宫颈癌组织中阳性表达率较高,其与宫颈癌的发生、发展有关,四者联合检测对早期诊断宫颈癌及临床治疗有重要意义。