Objective:To clarify the significance of the fractional anisotropy(FA) value and apparent diffusion coefficient(ADC) value of diffusion tensor imaging(DTI) applied in the glioma grading with Meta-analysis, and to provide a reference for selecting the treatment program and judging the prognosis of glioma.Methods:Computer search was performed in PubMed database, EMBASE database,CBM, CNKI, Wanfang database, and VIP database.The relevant neurosurgery magazines and neuroimaging magazines, the proceedings of academic meeting were retrieved by hand and the references of related reviews were retrospectively retrieved.Then the case-series studies according to inclusion and exclusion criteria were screened,and the qualities of included studies were evaluated.Meta-analysis was carried out by Review Manager 5.2 software.Results:Nine studies were included.The FA value of low-grade glioma(LGG) in tumor centre was lower than that of high-grade glioma(HGG) (χ2=11.94,df=8,P=0.15;I2=33%,Z=2.78,P=0.005;WMDFA=-0.02,95%CI:-0.03--0.01),and the ADC value of LGG in tumor centre was higher than that of HGG (χ2=5.26,df=4,P=0.26;I2=24%,Z=2.19,P=0.03;WMDADC=0.15,95%CI:0.02-0.28).Conclusion:When the FA value in tumor centre of the glioma is increasd,the ADC value is decreased,and the grade of glioma is increasd.The FA value and ADC value of DTI can help determine the grade of gliomas.%目的:采用Meta分析方法阐明弥散张量成像(DTI)的部分各项异性(FA值)值和表观弥散系数(ADC)值在胶质瘤分级中应用的意义,为胶质瘤治疗方案的选择与预后判断提供参考.方法: 计算机检索PubMed 数据库、EMBASE数据库、中国知网(CNKI)、万方数据库和维普数据库,手工检索神经外科学杂志、神经影像学杂志和有关神经外科的学术会议论文集,回溯检索综述性论文的参考文献,按纳入与排除标准选择病例系列研究、评价研究质量,采用Review Manager 5.2软件对所提取数据进行Meta分析. 结果: 共有9篇文献入选.低级别胶质瘤(LGG)肿瘤实质区的FA值低于高级别胶质瘤(HGG)肿瘤实质区的FA值,差异有统计学意义(χ2=11.94,df=8,P=0.15;I2=33%,Z=2.78,P=0.005;WMDFA值=-0.02,95%CI:-0.03~-0.01);LGG肿瘤实质区的ADC值高于HGG肿瘤实质区的ADC值,差异有统计学意义(χ2=5.26,df=4,P=0.26;I2=24%,Z=2.19,P=0.03;WMDADC值=0.15,95%CI:0.02~0.28).结论:胶质瘤实质区FA值越大,ADC值越低,胶质瘤的级别越高;DTI的 FA值和ADC值有助于确定胶质瘤的分级.
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