Pancreatic cancer is one of the most malignant solid tumors. Trans-arterial infusion chemotherapy has been used for the inoperable pancreatic cancers. The local drug concentration in intra-arterial infusion chemotherapy is much higher than that in intravenous chemotherapy. Thus, a better therapeutic effect can be surely achieved, the disease-related symptoms can be well improved, the patient's survival time can be markedly prolonged, and the liver metastases can be effectively reduced. This paper aims to suggest a more detailed and standardized therapeutic scheme to perform intra-arterial infusion chemotherapy for inoperable pancreatic cancers, focusing on the relevant concept, contraindications, indications, preoperative preparation, methods of operation, postoperative treatment, the prevention and treatment of complications, etc. The scheme will help domestic interventional physicians to make reasonable decisions in their clinical practice. Of course, the scheme proposed here is not a mandatory standard, and it can not resolve all the problems which might be encountered in employing intra-arterial infusion chemotherapy for patients with inoperable pancreatic cancer. Therefore , the interventional physicians should fully understand the most useful medical evidence of a given patient and sincerely take the patient's own will into consideration before an individualized and reasonable therapeutic plan is able to be worked out. (J Intervent Radiol, 2012, 21: 353-355)%胰腺癌是恶性度最高的实体肿瘤之一.对不能手术切除的胰腺癌,经动脉灌注化疗由于肿瘤局部药物浓度较静脉用药高,可以达到更好的治疗效果,在改善疾病相关症状、延长生存期、减少肝转移及发生肝转移后的治疗上均取得了令人瞩目的 成绩.本文在相关概念、禁忌证、适应证、术前准备、操作方法、术后处理及并发症的预防和处理等方面给出了较详尽的规范化建议,旨在帮助国内同行作出合理决策,但不是强制性标准,也不可能包括和解决胰腺癌经动脉灌注化疗中的所有问题.因此,在面对某一患者时,应在充分了解本病的最佳医学证据,结合患者具体病情及其意愿的基础上,为患者制定合理的诊疗计划.
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