Hedgehog信号通路与LKB1基因在乳腺癌中的达及其相关性研究

摘要

Hedgehog signaling pathway is excessive activated in breast cancer.LKBl is currently accepted as a tumor-suppressor gene,which can inhibit the proliferation of breast cancer.The overexpression of LKB1 can regulate the expression of CyclinDl series gene which is a target gene of Hedgehog signaling pathway.Meanwhile,the study found that PKA gene play an important role in Hedgehog signaling pathway,its activation is related with the cAMP state,and LKB1 genes can influence the cAMP state.Therefore,LKB1 gene and the Hedgehog signaling pathway may exist some inevitable connection.%Hedgehog信号通路在乳腺癌中过度激活,LKB1是抑癌基因,有抑制乳腺癌增殖的功能.LKB1过表达可调控Hedgehog信号通路的靶基因CyclinD1系列基因的表达,同时研究发现Hedgehog信号通路中PKA基因起重要作用,其激活与cAMP状态有关,而LKB1基因能影响cAMP的状态.因此,LKB1基因与Hedgehog信号通路可能存在某种必然的联系.