Mutation Frequency in BRCA1 and BRCA2 Genes Among Women with Breast Cancer in Kabardino-Balkaria

摘要

The study was conducted within the individual genotyping of healthy and sick women in the Kabardino-Balkarian Republic to determine the risk-prone groups with increased susceptibility to hereditary form of breast cancer development. Blood samplings were collected and total DNA was taken from 300 people (control and experimental groups). The frequency of 5382insC, 4154delA, 185delAG BRCA1 mutations and 6174delT mutations of the BRCA2 gene among women with breast cancer was studied. The data obtained along with the survey suggest the hereditary or sporadic nature of the disease. A comparative analysis of the frequencies of genes alleles towards susceptibility to the hereditary form of this disease will provide an opportunity to discover the genetic reasons for an increase in cancer and to identify the groups of the greatest risk.